论文部分内容阅读
MicroRNAs(miRNAs)是一类长度约为22 nt的内源性非编码小RNA.它们在后生动物基因组中普遍存在,通过抑制靶基因mRNA的翻译或将其降解,在转录后水平调控基因的表达.越来越多的证据表明,miRNAs在动物发育和人类疾病发生中发挥重要作用.miR-183基因簇在后口动物和原口动物中高度保守,编码miR-182、miR-96和miR-183.miR-183基因簇在动物感觉器官中特异性表达,对动物感觉器官的发育和功能至关重要.miR-183基因簇还与人类的肺癌、肝癌、乳腺癌、胰腺癌和黑色素瘤等多种癌症相关.miR-183基因簇在多种肿瘤细胞中异常表达,它们通过调控与肿瘤细胞分裂和死亡相关基因,而起到促进或抑制肿瘤发生的作用.本文对miR-183基因簇miRNAs在动物感觉器官功能和发育及人类肿瘤发生中的作用进行论述.
MicroRNAs (miRNAs) are a class of endogenous, non-coding small RNAs of about 22 nt in length that are ubiquitous in the metazoan genome and regulate gene expression at post-transcriptional level by inhibiting or degrading the translation of target mRNA There is growing evidence that miRNAs play an important role in the development of animals and in the development of human diseases.miR-183 gene cluster is highly conserved in back-mouth animals and protozoa and encodes miR-182, miR-96 and miR-183 The miR-183 gene cluster is specifically expressed in animal sensory organs and is crucial for the development and function of animal sensory organs. The miR-183 gene cluster is also associated with more human lung, liver, breast, pancreatic and melanoma cancers MiR-183 gene cluster abnormal expression in a variety of tumor cells, they regulate tumor cell division and death-related genes, which play a role in promoting or inhibiting tumorigenesis.In this paper, miRNA-183 gene cluster miRNAs in Animal sensory organ function and development and the role of human tumor occurrence are discussed.