Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.738

• 作 者: Xiangxi Meng Wenzhao Wang Zhou
• 机 构: StateKeyLaboratoryofMicrobialResources,UniversityofChineseAcademyofSciences,StateKeyLaboratoryofMyco
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2017年9期
• 关键词: 生物合成基因簇 弗氏链霉菌 调控机制 新霉素 Streptomyces RT-PCR分析 氨基糖苷类抗生素 蛋白质编码 neomycin regulation
• 基金项目: funded in part by the Ministry of Science and Technology of China（2015CB150600）, the National Natural Science Foundation of China（31370095 and 31522001）

Neomycins are a group of aminoglycoside antibiotics with both clinical and agricultural applications.To elucidate the regulatory mechanism of neomycin biosynthesis,we completed draft genome sequencing of a neomycin producer Streptomyces fradiae CGMCC 4.73