论文部分内容阅读
国际水稻基因组测序计划(IEGSP)顺利完成,水稻基因的研究也进入了后基因组研究阶段.水稻基因芯片数据注释分析是一项重要的功能基因组学研究内容,它为理解水稻基因的生物学意义提供了帮助.本研究开发了一个基于Web的水稻基因芯片数据注释和分析平台(Rice Chip),它比同类的注释数据库更加全面快捷.本平台共由5个功能模块组成:Bio Chip模块为水稻基因表达数据提供快速检索和高级检索,可依次按照Probe Set ID,Locus ID,Analysis Name等字段进行检索;Bio Anno模块整合多个生物学数据库,为水稻基因提供基因功能、蛋白质结构、生物代谢途径以及转录调控等方面的注释信息;BioSeq模块则收集水稻基因组的序列信息,支持对水稻基因与芯片探针的序列查询;BioView模块是系统图形可视化的核心模块,提供友好的访问界面与结果输出,方便研究人员使用;BioAnaly模块结合R/Bioconductor统计分析工具提供高通量芯片数据的在线分析.本系统从不同的方面依次提供了数据检索、基因注释、序列分析、数据可视化和数据分析等功能,其数据收集的全面性与功能分析的强大性在同类水稻基因芯片数据注释和分析平台中都较突出.
The successful conclusion of the International Rice Genome Sequencing Program (IEGSP) and the study of rice genes have also entered the post-genome research phase. The data annotation analysis of rice gene microarrays is an important functional genomics study that provides a basis for understanding the biological significance of rice genes This research has developed a Web-based rice gene chip data annotation and analysis platform (Rice Chip), which is more comprehensive than the same type of annotation database.This platform consists of five functional modules: the Bio Chip module is a rice gene The expression data provides quick and advanced searches, which can be followed by fields such as Probe Set ID, Locus ID, Analysis Name, etc. The Bio Anno module integrates multiple biological databases to provide rice genes with gene functions, protein structures, biological metabolic pathways and Transcriptional control and other aspects of the annotation information; BioSeq module is to collect sequence information of the rice genome, support for rice gene and chip probes sequence query; BioView module is the system graphics visualization of the core module to provide friendly access to the interface and the results output, convenient Researchers use BioAnaly module in combination with R / Bioconductor Statistical analysis tools provide on-line analysis of high-throughput chip data.The system provides functions such as data retrieval, gene annotation, sequence analysis, data visualization and data analysis in different aspects in order, the comprehensiveness of data collection and powerful analysis of functions Sex in the same kind of rice gene chip data annotation and analysis platform are more prominent.