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采用放射免疫、脑室微量注射等急性实验方法,探讨了大鼠内源性神经降压素对应激性胃溃疡的细胞保护作用。侧脑室注射抗神经降压素血清后,大鼠应激性胃溃疡的产生明显加剧(P<0.05)。在大鼠应激性胃溃疡产生的同时,其血浆内神经降压素样免疫活性物含量明显减少(P<0.05),而下丘脑、桥脑、延脑、垂体中神经降压素样免疫活性物含量明显升高(P<0.01)。结果提示,大鼠内源性神经降压素具有细胞保护作用,并可能参与应激性胃溃疡的形成过程。
Acute experimental methods such as radioimmunoassay and intraventricular microinjection were used to investigate the cytoprotective effects of rat endogenous neurotensin on stress gastric ulcer. After injection of anti-neurotensin serum in the lateral ventricle, the stress gastric ulcer in rats was significantly increased (P<0.05). At the same time as the stress gastric ulcer in rats, the content of neurotensin-like immunoreactive substances in plasma was significantly reduced (P<0.05), but neurotensin-like immunity in hypothalamus, pons, medulla, and pituitary was also observed. The content of active substances increased significantly (P<0.01). The results suggest that rat endogenous neurotensin has cytoprotective effects and may participate in the formation of stress gastric ulcer.