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目的探讨人重组生长素(rhGH)治疗大面积烧伤伴重度吸入性损伤的疗效。方法40例大面积烧伤伴重度吸入性损伤患者被随机分为治疗组及对照组,治疗组行烧伤常规治疗+rhGH治疗,对照组仅行烧伤常规治疗,观察两组治疗后营养状况(包括左上臂肌围、血红蛋白、总蛋白、白蛋白等)、创面愈合时间、机械通气时间及住院日。结果治疗后两组营养状况差异有统计学意义(P<0．05),治疗组植皮区、供皮区愈合时间,机械通气时间及住院日均优于对照组(P<0．05)。结论rhGH能促进创面愈合,改善营养状况,缩短机械通气时间。
Objective To investigate the effect of recombinant human growth hormone (rhGH) on severe burn injury with severe inhalation injury. Methods Forty patients with severe burn and severe inhalation injury were randomly divided into treatment group and control group. The treatment group was treated with rhGH by conventional burn therapy while the control group was treated with conventional burn therapy. The nutritional status of the two groups after treatment (including left upper Arm muscle circumference, hemoglobin, total protein, albumin, etc.), wound healing time, mechanical ventilation time and hospitalization days. Results There was significant difference in nutritional status between the two groups after treatment (P <0.05). The healing time, the time of mechanical ventilation and the length of hospitalization in the skin graft and donor area were all better than those in the control group (P <0.05). Conclusion rhGH can promote wound healing, improve nutritional status and shorten the time of mechanical ventilation.