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[目的]评价后续经动脉化疗栓塞术介入治疗胆管癌并阻塞性黄疸的临床疗效。[方法]回顾性分析53例胆管癌并阻塞性黄疸的临床资料,以治疗前后总胆红素降低、生存时间为观察指标,评价其治疗效果。并对可能的影响因素如性别、年龄、分化程度、术前胆红素水平、术前肝功、有无并发症、有无后续治疗等进行统计学分析。[结果]胆道内支架置入(EMBE)后,结合后续局部持续性化疗栓塞术,总胆红素及直接胆红素分别下降了153.2、80.1μmol/L,显著高于单纯行EMBE的前后差异(P﹤0.05);后续经动脉化疗栓塞术介入治疗组平均生存时间为(18.2±5.9)月,显著高于只进行EMBE的(3.9±1.2)月(P﹤0.05)。[结论]EMBE术治疗胆管癌并阻塞性黄疸,结合后续局部持续性化疗栓塞术,能够显著提高患者的生命质量,延长生存时间。
[Objective] To evaluate the clinical efficacy of subsequent interventional treatment of cholangiocarcinoma and obstructive jaundice by transcatheter arterial chemoembolization. [Methods] A retrospective analysis of 53 cases of cholangiocarcinoma and obstructive jaundice clinical data, before and after treatment to reduce total bilirubin, survival time as an indicator to evaluate the therapeutic effect. The possible influencing factors such as gender, age, differentiation, preoperative bilirubin, preoperative liver function, with or without complications, with or without follow-up treatment were statistically analyzed. [Results] The total bilirubin and direct bilirubin decreased by 153.2 and 80.1 μmol / L, respectively, after EMBS implantation combined with follow-up of local continuous chemoembolization, which was significantly higher than that of EMBE (P <0.05). The mean survival time was (18.2 ± 5.9) months in follow-up after transcatheter arterial chemoembolization (3.9 ± 1.2) months (P <0.05). [Conclusion] The EMBE treatment of cholangiocarcinoma and obstructive jaundice combined with follow-up of local continuous chemoembolization can significantly improve the quality of life of patients and extend the survival time.