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目的了解乙肝患者不同性别间HBV-DNA分布特征。方法荧光定量PCR用于定量检测21 650例乙肝患者HBV-DNA。结果男性和女性HBV-DNA总阳性率分别为61.22%和53.47%(χ2=119.50,P<0.000 1),男性和女性阳性率均逐年增高(分别为r=0.857 14,P=0.006 53和r=0.809 52,P=0.014 9),病毒载量均逐年下降(分别为r=-0.904 8,P=0.002 01和r=-0.857 1,P=0.006 53)。出现由高拷贝峰值的单峰分布到低拷贝峰值高拷贝为亚峰的双峰分布的特征。结论 HBV-DNA阳性率男性显著高于女性;两性阳性率均逐年增高,病毒载量均值均逐年下降;病毒载量无性别差异。
Objective To understand the distribution of HBV-DNA in different genders of hepatitis B patients. Methods Fluorescent quantitative PCR was used to quantitatively detect HBV-DNA in 21 650 hepatitis B patients. Results The positive rates of HBV-DNA in males and females were 61.22% and 53.47%, respectively (χ2 = 119.50, P <0.0001). The positive rates of HBV DNA in males and females were increased year by year (r = 0.857 14, P = 0.006 53 and r = 0.809 52, P = 0.014 9). The viral load decreased year by year (r = -0.904 8, P = 0.002 01 and r = -0.857 1, respectively; P = 0.006 53). The characteristics of the bimodal distribution appear as a monomodal distribution from a high-copy peak to a low-copy high-copy as a sub-peak. Conclusions The positive rate of HBV DNA was significantly higher in males than in females. The positive rate of both sexes increased year by year with the mean of viral load declining year by year. There was no gender difference in viral load.