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EMA药物风险管理委员会(PRAC)推荐加强限制女性使用丙戊酸盐由于宫内暴露于丙戊酸盐的胎儿存在发生畸形和发育问题的风险,PRAC推荐加强限制丙戊酸盐的使用。PRAC建议,除非其他治疔方法无效或不能耐受,否则丙戊酸盐不应用于治疗妊娠或有可能进入妊娠状态女性的癫痫或双
The EAC's Drug Risk Management Committee (PRAC) recommends strengthening restrictions on the use of valproate in women The risk of malformations and developmental problems occurring in fetuses exposed to valproate in the uterus has been suggested by the PRAC to enhance restrictions on the use of valproate. PRAC recommends that valproate should not be used to treat epilepsy in women with gestational or probable status of pregnancy or to be double unless other methods of treatment are ineffective or not tolerated