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目的 探讨进展期胃癌围手术期血清DNA聚合酶活性的变化。方法 采用放射性免疫法测定了 64例进展期胃癌、64例胃良性疾病患者的血清DNA聚合酶活性。 64例均经胃镜和大体病理确诊为进展期胃癌 ,观察手术前后血清DNA聚合酶活性的变化 ,并设置对照组 64例进行比较。结果 胃癌患者术前DNA聚合酶阳性率为 62 .5 % ,其中术后阳性率为 18.7% ,转阴率为 70 % ,其活性与临床分期无关 (P >0 .0 5 )而与组织学分级有关 (P <0 .0 5 ) ,明显高于对照组 (P <0 .0 1) ,特异性 93 .8% ,敏感性 62 .5 % ,准确性为 78%。结论 血清DNA聚合酶活性对于胃癌的诊断和治疗有一定意义。
Objective To investigate the changes of serum DNA polymerase activity during the perioperative period of advanced gastric cancer. Methods The serum DNA polymerase activity of 64 patients with advanced gastric cancer and 64 patients with benign gastric disease was determined by radioimmunoassay. Sixty-four patients were diagnosed as advanced gastric cancer by gastroscopy and gross pathology. Changes of serum DNA polymerase activity before and after surgery were observed. 64 patients in the control group were compared. Results The positive rate of preoperative DNA polymerase was 62.5 % in patients with gastric cancer, among which the positive rate was 18.7% after operation and the negative rate was 70%. The activity was not related to clinical stage (P > 0.05) and histological score Grade-related (P <0.05), significantly higher than the control group (P <0.01), specificity 93.8%, sensitivity 62.5%, and accuracy of 78%. Conclusion Serum DNA polymerase activity has a certain significance for the diagnosis and treatment of gastric cancer.