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免疫是机体抵抗外来侵袭和维护体内相对平衡的一种重要手段。如果人体自身相对免疫稳定功能失常,体内的平衡发生紊乱时,可导致自身免疫性疾病。自意大利Pernis和Vigliani(1958)提出矽肺发病的免疫学说~1后,各国学者进行了大量的研究,认为矽肺似属自身免疫性疾病~2。随着免疫学的进展,临床上治疗自身免疫性疾病,变态反应疾患,某些非特异性炎症和器官移植,都采用免疫抑制治疗~(3、4)。免疫抑制治疗是使用免疫抑制药
Immunization is an important means for the body to resist the external invasion and maintain the relative balance in the body. If the body’s own relative immune stability dysfunction, the balance of the body disorder, can lead to autoimmune diseases. Since Italy’s Pernis and Vigliani (1958) proposed the immunological theory of silicosis 1, a large number of studies have been conducted by scholars from various countries and considered that silicosis is an autoimmune disease ~ 2. With the progress of immunology, immunosuppressive therapy is used in the treatment of autoimmune diseases, allergic diseases, some nonspecific inflammation and organ transplantation clinically (3,4). Immunosuppressive therapy is the use of immunosuppressive drugs