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Objective: The purpose of this study was to examine the relationship between cytokine genotypes and preeclampsia. Study design: We conducted a case-control study that examined cytokine genotypes among 150 primiparous preeclamptic women and 661 primiparous, normotensive women. Analyses were adjusted for age, prepregnancy cigarette smoking, and education. Results: Preeclamptic white women were more likely than normotensive white women to carry the up-regulating tumor necrosis factor-α -308 A/A (odds ratio, 4.1; 95% CI, 1.1-15.3) genotype. Both black and white women with preeclampsia were more likely than normotensive control subjects to carry the interleukin-1α -producing-4845 G/G genotype (black odds ratio, 11.6; 95% CI, 1.5-89.3; white odds ratio, 1.7; 95% CI, 0.7-3.9), -889 C/C genotype (black odds ratio, 5.1; 95% CI, 0.6-41.6; white odds ratio, 1.9; 95% CI, 0.8-4.7), and the interleukin-1α -4845/interleukin-1α -889/tinereukin-1β -3957 GCC/GCC haplotype (black odds ratio, 3.4; 95% CI, 1.3-8.7; white odds ratio, 2.1; 95% CI, 1.4-3.2). Conclusion: Cytokine genotypes were associated with preeclampsia and may identify women who are at high risk for preeclampsia.
Objective: The purpose of The study was to examine the relationship between cytokine genotypes and preeclampsia. Study design: We conducted a case-control study that examined cytokine genotypes among 150 primiparous preeclamptic women and 661 primiparous, normotensive women. Analyzes were adjusted for age, prepregnancy cigarette smoking, and education. Results: Preeclamptic white women were more likely than normotensive white women to carry the up-regulating tumor necrosis factor-α-308 A / A (odds ratio, 4.1; 95% CI, 1.1-15.3) . Both black and white women with preeclampsia were more likely than normotensive control subjects to carry the interleukin-1α -producing-4845 G / G genotype (black odds ratio, 11.6; 95% CI, 1.5-89.3; 95% CI, 0.7-3.9), -889 C / C genotype (black odds ratio 5.1; 95% CI 0.6-41.6; white odds ratio 1.9; 95% CI 0.8-4.7), and the interleukin-1 alpha -4845 / interleukin-1α-889 / tinereukin-1β-3957 GCC / GCC haplotype (black odds ratio, 3.4; 95 % CI, 1.3-8.7; white odds ratio, 2.1; 95% CI, 1.4-3.2). Conclusion: Cytokine genotypes were associated with preeclampsia and may identify women who are at high risk for preeclampsia.