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目的测定肝脏病与糖代谢异常的关系。方法利用葡萄糖氧化酶法测定了１２例肝硬化、１１例急性肝炎和１５例慢性肝炎低血糖、糖耐量异常（ＩＧＴ）的发生率，利用放免法测定上述患者血Ｃ肽水平。结果３８例肝病患者中８例次住院过程中发生低血糖。肝脏病患者有相当比例的ＩＧＴ发生率，３８例患者中口服葡萄糖耐量试验（ＯＧＴＴ）异常１７例，占全部病例的４４．７％．肝脏病患者尽管有相当比例的ＩＧＴ发生率，但胰岛分泌正常，Ｃ肽水平与正常相比无明显差异。结论肝病时可有多种类型的糖代谢障碍，糖原分解和异生作用减弱易发生低血糖，而服糖后肝处理糖负荷能力减弱又易发生糖耐量异常，低血糖和糖耐量异常都会对病人产生不利的影响，所以对这类疾病应引起足够的重视。
Objective To determine the relationship between liver disease and abnormal glucose metabolism. Methods The incidence of hepatic cirrhosis, 11 cases of acute hepatitis and 15 cases of chronic hepatitis with hypoglycemia and impaired glucose tolerance (IGT) were measured by glucose oxidase method. The levels of serum C-peptide in these patients were determined by radioimmunoassay. Results 38 patients with liver disease occurred in 8 cases during hospitalization hypoglycemia. A significant proportion of patients with liver disease IGT incidence, 38 patients with oral glucose tolerance test (OGTT) in 17 cases, accounting for 44.7% of all cases. Despite a significant proportion of patients with liver disease IGT incidence, but normal pancreatic secretion, C-peptide levels compared with the normal no significant difference. Conclusions There are many types of glycometabolic disorders in liver disease, hypoglycemia and hypoxia are prone to hypoglycemia, but the ability of hepatic glycogen handling after weaning is weakened and glucose tolerance abnormalities are easy to occur. Both hypoglycemia and impaired glucose tolerance Adverse effect on the patient, so should pay enough attention to these diseases.