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目的探讨血管球瘤(GT)的临床及病理学特征。方法回顾性分析32例血管球瘤的临床资料、组织学形态及免疫组化染色结果。结果血管球瘤好发于甲下,疼痛明显;组织学上瘤细胞呈规则的圆形,胞质淡嗜伊红色,细胞境界清晰,核圆形、居中,瘤细胞巢间可见丰富的薄壁血管,间质含丰富的神经纤维和肥大细胞。免疫组化示vimentin、SMA和HHF-35(+),S-100和CD34(-)。结论血管球瘤多属于良性肿瘤,来源于血管球变异的平滑肌,结合其临床症状、好发部位、组织病理学特点和免疫组化标记可做出准确诊断。恶性血管球瘤要慎诊断,而疼痛可能与神经纤维、肥大细胞之间相互作用有关。
Objective To investigate the clinical and pathological features of glomus tumors (GT). Methods Retrospective analysis of 32 cases of glomus tumors clinical data, histological morphology and immunohistochemical staining results. The results of glioma occurred in a hypothyroidism, pain was obvious; histological tumor cells showed a regular round, cytoplasm pale eosinophilic, clear cell boundaries, nuclear round, centered, tumor cells can be seen in the nest between the rich thin-walled Vascular, interstitial rich in nerve fibers and mast cells. Immunohistochemistry showed vimentin, SMA and HHF-35 (+), S-100 and CD34 (-). Conclusions Most of glomus tumors are benign tumors, which originate from the smooth muscle of the glomerulus. Combined with the clinical symptoms, the location of the predilection, the histopathological features and the immunohistochemical markers, the accurate diagnosis can be made. Malignant glioma should be diagnosed carefully, and the pain may be related to the interaction between nerve fibers and mast cells.