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目的探讨抗代谢药物8-氯腺苷(8-Cl-A)眼局部应用对兔实验性视网膜新生血管的抑制作用。设计实验研究。研究对象纯种青紫兰家兔40只。方法采用视网膜静脉直接光凝法建立兔视网膜静脉阻塞(RVO)模型。分别设立对照组及8-Cl-A给药组,每组各20只(20眼)。于造模后次日治疗组每日球后注射8-Cl-A 9mg(计10日),对照组注射等体积生理盐水,采用荧光素眼底血管造影观察注射后2周内2组兔视网膜新生血管的发生率,并进行统计学分析。主要指标视网膜新生血管发生率及程度。结果RVO对照组20眼中,17跟发生视网膜新生血管:8-Cl-A治疗组20眼中3眼发生光凝点远端的视网膜新生血管(P= 0.000),且发生的程度及范围小于对照组,同时未见视网膜静脉侧支循环的建立。结论8-Cl-A可有效抑制兔实验性视网膜新生血管的发生。在视网膜血管增生性病变治疗中可能具有潜在的临床应用价值。
Objective To investigate the inhibitory effect of topical application of anti-metabolite 8-chloro-adenosine (8-Cl-A) on experimental retinal neovascularization in rabbits. Design experiment research. The research object purebred Cymbidium rabbit 40. Methods Rabbit retinal vein occlusion (RVO) model was established by retinal vein photocoagulation. The control group and the 8-Cl-A administration group were set up, with 20 eyes in each group (20 eyes). The rats in the treatment group were injected with 8-Cl-A 9 mg daily for 10 days after the modeling, and the control group was injected with equal volume of normal saline. Fluorescein angiography was used to observe the retinal neovascularization Vascular incidence, and statistical analysis. The main indicators of retinal neovascularization incidence and extent. Results In the 20 eyes of RVO control group, retinal neovascularization (P = 0.000) occurred in 3 of 20 eyes of retinal neovascularization with retinal neovascularization and 8-Cl-A treatment group (P = 0.000), and the extent and extent of retinal neovascularization were smaller than that of control group , While no retinal vein collateral circulation was established. Conclusion 8-Cl-A can effectively inhibit experimental retinal neovascularization in rabbits. In the treatment of retinal vascular proliferative lesions may have potential clinical value.