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正常的狗胆汁中未能分离出细菌Ｌ型或细菌型；体外胆汁诱导试验显示狗的胆汁可诱导出革兰氏阴性细菌的Ｌ型；将大肠杆菌（ＡＴＣＣ２５９２２）注入狗胆囊内４８小时后抽取胆汁进行培养，结果显示细菌型与Ｌ型均生长。另一组狗胆囊内注射大肠杆菌（ＡＴＣＣ２５９２２）Ｌ型。将胆囊内注射细菌型和Ｌ型的狗喂养６个月后，其胆汁中仍能分离出细菌型合并Ｌ型。取胆囊作病理切片，显微镜下可见胆囊呈慢性炎症改变：粘膜轻度萎缩、粘膜下有白细胞、淋巴细胞浸润，粘膜细胞内可找到细菌Ｌ型，囊壁内有轻度纤维增生。
Bacterial L-forms or bacterial forms were not isolated from normal dog bile; in vitro bile induction tests showed that dog bile induced L gram of gram-negative bacteria; E. coli (ATCC 25922) was injected 48 hours into the dog gallbladder Bile culture, the results showed that both bacterial and L-type growth. Another group of dogs were injected intragastrically with E. coli (ATCC25922) L form. Gallbladder inoculation of bacteria and L-type dogs fed 6 months after the bile can still be isolated from the bacterial form of L-type. Take the gallbladder for pathological sections, the gallbladder showed chronic inflammatory changes under the microscope: mucosal mild atrophy, submucosal leukocytes, lymphocytes infiltration, mucosal cells can be found in bacteria L-type, mild fibrous wall proliferation.