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我们曾发现空肠弯曲菌４３ｋＤ热休克蛋白（ＨＳＰ４３）能诱导小鼠产生自身免疫应答，本文则进一步分析了这种诱导作用的机理。二株针对ＨＳＰ６０保守区序列的单克隆抗体ＩＩＨ９和ＭＬ－３０不但能结合人及小鼠细胞中ＨＳＰ６０家族成员，而且也能结合ＨＳＰ４３，表明ＨＳＰ４３、人及小鼠ＨＳＰ６０三者均属同一家族成员，具有序列上的高度同源性。小鼠用空肠弯曲菌免疫后出现了针对１０种菌体蛋白的抗体，其中最早被诱导的抗体是针对ＨＳＰ４３的，并且该种抗体在随后８０ｄ观察期间内保持了较高活性，表明ＨＳＰ４３是优势抗原。本文结果提示，ＨＳＰ４３较易被免疫系统识别而产生应答，通过和宿主ＨＳＰ６０高度序列同源性而可能呈现分子模拟，从而诱导自身免疫损伤。
We have found that 43kD heat shock protein (HSP43) of Campylobacter jejuni can induce autoimmune response in mice, and the mechanism of this induction is further analyzed in this paper. Two monoclonal antibodies directed against the conserved region of HSP60, IIH9 and ML-30, not only bind HSP60 family member in human and mouse cells, but also bind HSP43, indicating that both HSP43, human and mouse HSP60 belong to the same family member , With a high degree of sequence homology. After immunization with Campylobacter jejuni, mice showed antibodies against 10 kinds of bacterial proteins. Among them, the earliest induced antibody was against HSP43, and the antibody maintained high activity during the following 80 days of observation, indicating that HSP43 is the predominant antigen. Our results suggest that HSP43 is more likely to be recognized by the immune system and responds to it and may show molecular mimicry through its high degree of sequence homology with the host HSP60 to induce autoimmune damage.