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目的 观察小剂量米非司酮用于紧急避孕的临床效果。方法 在无保护性交 3d内就诊、要求采用补救措施以防意外妊娠的健康妇女 35 2例 ,空腹口服米非司酮 10mg ,每日 1次 ,连服 3次。结果 实际妊娠 2例 ,显著低于预期妊娠的2 9.81%例 (P <0 .0 0 1) ,避孕有效率为 93.3%。副反应发生率为 2 0 .5 % ,均能耐受 ,少许阴道流血发生率为 8.0 % ,月经延迟发生率 2 4.7%。结论 小剂量米非司酮用于紧急避孕 ,安全、有效、经济、简便。
Objective To observe the clinical effect of low dose mifepristone for emergency contraception. Methods During the period of unprotected intercourse for 3 days, 352 healthy women requiring remedial measures to prevent unplanned pregnancy were given oral mifepristone 10 mg once daily for 3 times. Results The actual pregnancy was 2 cases, which was significantly lower than that of the expected pregnancy (9.81%, P <0.01). The effective rate of contraception was 93.3%. The incidence of side effects was 20.5%, were able to tolerate a little vaginal bleeding was 8.0%, the incidence of delayed menstruation was 4.7%. Conclusion Low dose mifepristone is safe, effective, economical and convenient for emergency contraception.