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目的 观察纳络酮对新生儿缺氧缺血性脑病的临床疗效。方法 对 32例缺氧缺血性脑病的患儿使用纳络酮治疗 ,均给予静脉用药 ,第 1天 0 4mg加入 1 0 %葡萄糖 30ml中静滴 ,第 2、3天给 0 8mg加入1 0 %葡萄糖 50ml中静滴 ,每次在 4h左右滴完 ,连续 3d。结果 32例缺氧缺血性脑病中 ,重度 1 7例 ,存活1 1例 ,死亡 6例 ,留后遗症 4例 ;中度 8例 ,存活 7例 ,死亡 1例 ,留后遗症 1例 ;轻度 7例 ,均存活 ,无后遗症发生。结论 新生儿缺氧缺血性脑病使用纳络酮能提高成活率 ,减少后遗症的发生
Objective To observe the clinical effect of naloxone on neonatal hypoxic-ischemic encephalopathy. Methods Thirty-two children with hypoxic-ischemic encephalopathy were treated with naloxone. All patients were given intravenous drug. On day 1, 0.4 mg of 10 mg glucose was added to 30 ml of intravenous drip. On the 2nd and 3rd days, 10 mg % Glucose in 50ml intravenous drip, drip every 4h or so, continuous 3d. Results Among the 32 cases of hypoxic-ischemic encephalopathy, 17 cases were severe, 11 cases survived, 6 died, 4 cases remained sequelae, 8 cases were moderate, 7 survived, 1 died and 1 case left sequelae. Mild 7 cases, all survived, no sequelae occurred. Conclusions The use of naloxone in neonatal hypoxic-ischemic encephalopathy can improve the survival rate and reduce the occurrence of sequelae