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The treatment of chronic hepatitis C (CMC) is still far from optimal, particularly for those subpopulations that do not respond to the standard combination therapy with Interferon-α(IFNα) plus ribavirin. Although in some cases the use of higher doses or longer treatment periods may be effective, these approaches are generally associated with a higher incidence of adverse events, which may either lead to a reduction in patient compliance or require drug withdrawal. IFNβcould represent an interesting alternative for treating CMC patients. Controversial data about IFNp efficacy in CMC exist, the main reason being that many results stem from pilot studies with small cohorts of patients. However, promising results have been obtained in some subgroups of patients that fail to respond to IFNa. Additionally, the good tolerability of IFNβrepresents an important advantage of the drug. The rates of dropouts in controlled clinical trials, as well as the need for dose reductions or treatment discontinuation are very low. It might be worth assessing the value of IFNβplus ribavirin in randomized studies with a larger cohort of patients, not eligible or not tolerating standard therapy, and for non-responders.
The treatment of chronic hepatitis C (CMC) is still far from optimal, particularly for those subpopulations that do not respond to the standard combination therapy with Interferon-α (IFNα) plus ribavirin. Although in some cases the use of higher doses or longer treatment periods may be effective, these approaches are more associated with a higher incidence of adverse events, which may either lead to a reduction in patient compliance or require drug withdrawal. IFNβcould represent an interesting alternative to CMC patients. Controversial data about IFNp efficacy in CMC exists, the main reason being that many results stem from pilot studies with small cohorts of patients. However, promising results have been obtained in some subgroups of patients that fail to respond to IFNa. drug. The rates of dropouts in controlled clinical trials, as well as the need for dose reductions or treatment di scontinuation are very low. It might be worth assessing the value of IFNβ plus ribavirin in randomized studies with a larger cohort of patients, not eligible or not tolerating standard therapy, and for non-responders.