First way of enantioselective synthesis of moxifloxacin intermediate

• 作 者: LI GuangXun WU Lei FU QingQuan TANG Zhuo ZHANG XiaoMei
• 机 构: Natural Products Research Center,Chengdu Institution of Biology,Chinese Academy of Science,Key Labor
• 出 处: Science China(Chemistry)
• 发表日期: 2013年03期
• 关键词: chiral reagent purification steps carboxylic antibacterial benzyl ethanol operat

A new method of enantioselective synthesis of(S,S)-2,8-diazobicyclo [4.3.0] nonane was found by using(R)-2-amino-2phenyl-ethanol as chiral induction reagent.The entire synthetic process included 8 steps which were easy to operate with high yield.The purification method was only simple recrystallization or even used directly in the next step without further purification.The total yield was 29%.

A new method of enantioselective synthesis of (S, S) -2,8-diazobicyclo [4.3.0] nonane was found by using (R) -2-amino-2phenyl-ethanol as chiral induction reagent. steps which were easy to operate with high yield. The purification method was only simple recrystallization or even used directly in the next step without further purification. The total yield was 29%.