论文部分内容阅读
妊娠期由于雌、孕激素的作用,胰岛出现结构和功能上的变化,β细胞明显肥大和增生,胰岛素的分泌随孕周而逐渐增多,形成高胰岛素血症,但同时由于胎盘分泌的皮质醇、雌激素、孕酮等多种对抗胰岛素的激素,导致周围组织对胰岛素反应的敏感性下降。此外,胎盘还能分泌胰岛素酶,加速胰岛素的降解,这些因素使孕妇体内胰岛素抵抗逐渐加重,表现为血糖升高,最终发生妊娠糖尿病(GDM)[1]。1糖化血红蛋白(Hb A1C)是红细胞内血红蛋白(Hb)与
Pregnancy due to the role of estrogen and progesterone, pancreatic islet structure and function changes, significant hypertrophy and proliferation of β cells, insulin secretion gradually increased with gestational age, the formation of hyperinsulinemia, but at the same time due to placental secretion of cortisol , Estrogen, progesterone and other anti-insulin hormones, leading to the surrounding tissue on the insulin response decreased sensitivity. In addition, the placenta can also secrete insulin, accelerating the degradation of insulin, these factors make pregnant women gradually increased insulin resistance, manifested as elevated blood sugar, the final occurrence of gestational diabetes (GDM) [1]. 1 Hb A1C is red blood cell hemoglobin (Hb) and