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在Ａｇ／ＡｇＣｌ电极的双室扩散池中测定不同电场对模型药物甲硝唑（１）通过离体大鼠皮肤渗透速率的影响。结果表明，１生理盐水饱和液阳极导入时的透皮速率是被动扩散的２．３倍，阴极导入时药物的透皮速率是其被动扩散的４５％，说明电渗作用明显促进了分子型药物１的经皮渗透；与药物渗透方向相反的电渗流则明显阻碍其经皮渗透
The effect of different electric fields on the permeation rate of model drug metronidazole (1) through the isolated rat skin was determined in a two-chamber diffusion cell of Ag / AgCl electrode. The results showed that the transdermal rate of the saturated saline solution was 2.3 times that of the passive diffusion and the transdermal rate of the drug was 45% of that of the passive diffusion when the cathodes were introduced, indicating that the electro-osmosis obviously promoted the molecular drug 1 transdermal penetration; electro-osmotic flow in the opposite direction to drug permeation significantly hindered its transdermal penetration