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氧化还原因子 1(Ref 1)是一种多功能蛋白酶 ,其主要作用是对氧化性损伤的DNA进行修复和调节转录因子的DNA结合活性。本文重点综述其生物学功能及其在氧化性损伤对p5 3调节、肿瘤、缺血性脑损伤中的研究进展
Redox factor 1 (Ref 1) is a multifunctional protease whose primary function is to repair oxidatively damaged DNA and to regulate the DNA-binding activity of transcription factors. This review focuses on the biological function and its progress in the study of oxidative damage on p5 3, tumor and ischemic brain injury