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目的 观察术前选择性动脉灌注化疗加栓塞对中晚期直肠癌的近期治疗效果。方法 选择 6 3例经活检证实的中晚期直肠癌患者 ,经直肠上动脉或双侧髂内动脉造影确定肿瘤的主要供血动脉 ,向内注入 40 %碘化油及化疗药物混合的乳剂 ,其它靶血管内注入化疗药物 ( 5 Fu +MMC +DDP) ,治疗后观察患者肠出血、脓血便、肛门下坠、肠梗阻等症状的缓解情况及术中肿瘤的游离难易度、创面出血情况。结果 治疗后患者肠出血、脓血便、肛门下坠及不全性肠梗阻症状得到明显缓解 ,术中肿瘤与周围组织间隙明显、利于游离 ,创面出血少。结论 术前行选择性动脉灌注化疗加栓塞可改善中晚期直肠癌患者的临床症状 ,提高切除率 ,可能对直肠癌根治术后肿瘤的复发和肝转移有预防作用。
Objective To observe the short-term therapeutic effect of preoperative selective arterial infusion chemotherapy and embolization on advanced rectal cancer. Methods Totally 63 patients with advanced and rectal cancer confirmed by biopsy were selected. The main feeding arteries of the tumor were confirmed by angiography of upper rectal artery or bilateral internal iliac artery. Injecting 40% iodized oil and chemotherapy drug mixed emulsion, the other targets Intravascular chemotherapy drugs (5 Fu + MMC + DDP) were used to observe the relief of intracranial hemorrhage, pus and blood stool, anal fall, intestinal obstruction and intraoperative free tumor ease and wound bleeding. Results After treatment, patients with intestinal bleeding, pus and blood, anal fall and incomplete intestinal obstruction symptoms were significantly alleviated, intraoperative tumor and the surrounding tissue clearance was obvious, conducive to free, less bleeding wounds. Conclusion Preoperative selective arterial infusion chemotherapy and embolization can improve the clinical symptoms of patients with advanced and advanced rectal cancer, improve the resection rate, may have a preventive effect on tumor recurrence and liver metastasis after radical resection of rectal cancer.