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流行病学资料提示脑膜瘤的生长可能受性激素影响.颅内脑膜瘤性别之比女∶男为2∶1,椎管内为4∶1.女性脑膜瘤常在内分泌变更期间如月经末期或孕娠期发现,这可能是由于血管扩张或内分泌变化影响了其生长.此外,它常与乳癌并存.为了了解此种关系,作者对10例(男女各5例)脑膜瘤组织进行了雌激素、孕酮或雄激素受体的研究.并对3例其他类型脑瘤作了同样检查以资对照.作者在手术时即将肿瘤分成两部分,一部分作组织病理切片,另一部分在切下后15分钟内储存在-80℃条件下直到进行受体检查.为了解血液内性激素水平,术前一天采取血标本用放射免疫法测定血浆雌二醇、孕酮和皋酮.细胞激素受体采用稍为修正的检查乳癌和子宫组织内受体所用的方法.
Epidemiological data suggest that the growth of meningiomas may be affected by sex hormones.The sex ratio of intracranial meningioma female: male 2: 1, 4: 1 spinal canal. Female meningioma often during endocrine changes such as the end of menstruation or pregnancy Pregnancy found that this may be due to vasodilation or endocrine changes affect its growth, in addition, it often coexists with breast cancer.In order to understand this relationship, the authors of 10 cases (5 men and 5 women) meningiomas estrogen, Progesterone orrogen receptor and three other types of brain tumors were also checked for control.At the time of surgery the tumor is divided into two parts, part of the histopathology, the other part of the 15 minutes after the cut Stored at -80 ℃ conditions until the receptor test. In order to understand the level of sex hormones in blood, the day before surgery to take blood samples by radioimmunoassay of plasma estradiol, progesterone and Gao Huo. Cytokine receptor with a slight correction Methods for examining receptors in breast and uterine tissues.