论文部分内容阅读
许多人报告肾功能衰竭患者有听力障碍的高发率,但肾功能衰竭还有耳毒性药物、遗传性疾病、噪声、年龄、糖尿病、肾透析等因素的复杂影响,很难说肾功能衰竭是听力障碍的诱因。作者在动物实验中,排除其他主要原因,研究了肾功能衰竭与听力障碍的关系。实验用18只白豚鼠,腹腔注入硫喷妥钠后,行下腹部正中切开,在膀胱和输尿管交界的上方约1 cm处,用丝线结扎输尿管,另一侧输尿管以速凝粘合剂使狭窄,造成肾功能衰竭。术后6～15天测耳蜗电位。结果:(1)AP:振幅和潜伏期均正常者6只,振幅下降而潜伏期正常者3只,振幅下降潜伏期也延长者4只,另5只无反应。CM各频率均正常者2只,部分频率正常者4只,各频率均异常者6只,另3只无反应。12只豚鼠用于测EP,其平均值为92±9.4～80mV,全都在正常范围。在
Many people report a high prevalence of hearing impairment in patients with renal failure, but there are complex effects of ototoxic drugs, genetic disease, noise, age, diabetes, renal dialysis and other factors on renal failure. It is difficult to say that renal failure is a hearing impairment The incentive. In animal experiments, the author excluded other major causes and studied the relationship between renal failure and hearing impairment. In the experiment, 18 guinea pigs were injected intraperitoneally with thiopental, and the lower abdomen was dissected. The ureter was ligated with silk thread about 1 cm above the junction of the bladder and the ureter. The other ureter was made of quick-setting adhesive Narrow, resulting in renal failure. Postoperative cochlear potential 6 to 15 days. Results: (1) AP: 6 rats with normal amplitude and latency, 3 patients with normal amplitude and 4 patients with prolonged latency, and 5 patients with no response. CM frequency of 2 were normal, part of the normal frequency of 4, the frequency of abnormal 6, the other 3 no response. Twelve guinea pigs were tested for EP, with an average of 92 ± 9.4 to 80 mV, all in the normal range. in