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健康男性志愿受试者１６人（蒙古族８名，汉族８名）每人单剂量口服替硝唑２ｇ，采用高效液相色谱法测定血药浓度，研究其药代动力学过程。结果表明：蒙、汉族替硝唑药代动力学参数分别为Ｔ１／２（Ｋａ）：０．８６±０．５ｈ和１．２２±０．１２ｈ；Ｔ１／２（Ｋｅ）：１４．７３±４．３３ｈ和１３．０４±１．４４ｈ；Ｔｐｅａｋ：３．３５±１．８１ｈ和４．１２±１．５４ｈ；Ｃｍａｘ３８．８９±７．８０ｍｇ·Ｌ－１和３７．５８±３．９７ｍｇ·Ｌ－１；Ｖ／Ｆ：４３．５８±３．９０Ｌ和４５．６０±８．４０Ｌ。蒙、汉两组的各项药代动力学参数经统计学分析处理，皆无显著性差异（Ｐ＞０．０５）。
16 healthy volunteers (8 Mongolian and 8 Han nationals) were given oral tinidazole 2 g per person, and their pharmacokinetics were determined by high performance liquid chromatography (HPLC). The results showed that the pharmacokinetic parameters of tinidazole in Mongolian and Han nationality were T1 / 2 (Ka): 0.86 ± 0.5h and 1.22 ± 0.12h respectively; T1 / 2 (Ke): 14.73 ± 4.33 h and 13.04 ± 1.44 h; Tpeak: 3.35 ± 1.81 h and 4.12 ± 1.54 h; Cmax 38.89 ± 7.80 mg · L-1 and 37.58 ± 3.97 mg · L-1; V / F: 43.58 ± 3.90L and 45.60 ± 8.40L. There was no significant difference in the pharmacokinetic parameters between Mongolian and Han patients (P> 0.05) after statistical analysis.