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目的比较角膜缘干细胞移植术和羊膜移植术治疗复发性翼状胬肉的临床疗效。方法将56例(68眼)患者随机分为两组,分别采用角膜缘干细胞移植术(27例33眼)和羊膜移植术(29例35眼)治疗,术后随访6个月至2年。结果角膜缘干细胞移植组1眼复发,复发率为3.03%;羊膜移植组8眼复发,复发率为22.86%,两组比较有显著性差异(,χ2=5.814,p<0.05)。角膜创面上皮平均愈合时间角膜缘干细胞移植组为4.73天,羊膜移植组为6.38天,两组比较有显著性差异(t=4.629,p<0.05)。结论角膜缘干细胞移植术治疗复发性翼状胬肉复发率低,角膜创面修复快,是一种理想的手术方法,值得推广应用。
Objective To compare the clinical efficacy of limbal stem cell transplantation and amniotic membrane transplantation in the treatment of recurrent pterygium. Methods Fifty-six patients (68 eyes) were randomly divided into two groups. They were treated with limbal stem cell transplantation (27 cases, 33 eyes) and amniotic membrane transplantation (29 cases, 35 eyes) respectively. The patients were followed up for 6 months to 2 years. Results One limbal stem cell transplantation group had a recurrence rate of 3.03%. In the amniotic membrane transplantation group, 8 eyes had a relapse rate of 22.86%. There was significant difference between the two groups (χ2 = 5.814, p <0.05). The average healing time of corneal wound epithelium was 4.73 days in limbal stem cell transplantation group and 6.38 days in amniotic membrane transplantation group, there was a significant difference between the two groups (t = 4.629, p <0.05). Conclusion The limbal stem cell transplantation for the treatment of recurrent pterygium recurrence rate is low, corneal wound repair fast, is an ideal surgical method, it is worth promoting the application.