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目的:用Meta-分析方法评价中药治疗迁延性腹泻的疗效和安全性。方法:计算机检索PubMed、Cochrane library、中国学术期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、万方数据资源系统(WangFang Data)数据库,收集中药治疗迁延性腹泻的随机对照试验。采用Cochrane协作网的质量评价标准并用其提供的软件RevMan5.0,对纳入试验的临床总有效率及不良反应进行统计分析。结果:共计纳入29篇随机对照试验治疗3028名患者。所纳入的文献质量普遍偏低。23个中药内服与西药治疗比较的试验中有20个研究结果显示试验组疗效优于对照组,3个研究显示两组统计结果差异无统计学意义;5个中药外治与西药治疗比较的试验中有4个研究结果显示试验组疗效优于对照组,1个研究显示两组结果无统计学意义。从干预措施整体比较,中药内服或中药外治治疗迁延性腹泻临床总有效率优于西药治疗。中药内服治疗未发现明显不良反应,中药外治出现皮肤红色丘疹。结论:中药治疗迁延性腹泻具有较好的疗效,但方法学方面亟待提高。
OBJECTIVE: To evaluate the efficacy and safety of traditional Chinese medicine in treating persistent diarrhea by Meta-analysis. Methods: PubMed, Cochrane library, CNKI, VIP and WangFang Data databases were searched by computer. A randomized controlled trial of traditional Chinese medicine in the treatment of persistent diarrhea was conducted. Using the Cochrane Collaboration’s quality evaluation criteria and using the software RevMan 5.0 provided by it, a statistical analysis of the total clinical efficacy and adverse reactions included in the trial was performed. RESULTS: A total of 30 randomized controlled trials involving 3028 patients were enrolled. The quality of the included literature is generally low. Twenty-three trials of 23 Chinese herbal medicine oral administration and Western medicine treatment comparison showed that the experimental group had better curative effect than the control group, three studies showed no statistically significant difference between the two groups; Four of the studies showed that the efficacy of the experimental group was better than that of the control group. One study showed no significant difference between the two groups. From the overall comparison of interventions, traditional Chinese medicine or external medicine treatment of diarrhea persistent clinical efficacy is better than Western medicine. Chinese medicine oral administration found no obvious adverse reactions, Chinese medicine outside the skin appear red papules. Conclusion: Chinese medicine treatment of persistent diarrhea has a good effect, but the methodology needs to be improved.