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目的:研究黄连总生物碱与药物树脂的交换动力学与热力学。方法:选用黄连总生物碱,以IRP88弱酸K+型离子交换树脂为载体,通过静态离子交换,考察反应温度、药物浓度、不同pH值对交换过程的影响,并对交换动力学曲线进行拟合,计算不同条件下药物树脂交换反应速率常数以及交换反应热力学常数。结果:反应温度越高,药物浓度越高,交换进行得越快,达到平衡所需时间越短;药液pH5.0时离子交换量最大;拟合显示交换反应为一级可逆反应,交换反应活化能Ea=17.599 kJ.mol-1;交换反应热△H0=0.249 7 kJ.mol-1。结论:药物与树脂的交换速度和程度受反应温度、药物浓度和药液pH值的影响;交换反应为自由能减少,熵增加的过程,可自发进行。
Objective: To study the exchange kinetics and thermodynamics of total alkaloids from Coptis chinensis and drug. Methods: The effects of reaction temperature, drug concentration and different pH on the exchange process were studied by static ion exchange with the IRP88 weak acid K + ion exchange resin as the carrier. The exchange kinetics curves were fitted, The resin resin exchange reaction rate constants and the exchange reaction thermodynamic constants were calculated under different conditions. Results: The higher the reaction temperature was, the higher the drug concentration was. The faster the exchange was, the shorter the time required to reach equilibrium was. The highest ion exchange capacity was obtained at pH 5.0. The fitting showed that the exchange reaction was first order reversible reaction and exchange reaction Activation energy Ea = 17.599 kJ · mol-1; Exchange reaction heat △ H0 = 0.249 7 kJ · mol-1. CONCLUSION: The exchange rate and degree of drug and resin are affected by the reaction temperature, drug concentration and pH value of the liquid. The exchange reaction is the process of decrease of free energy and increase of entropy, which can be carried out spontaneously.