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采用阳极氧化法在纯钛表面构建三维纳米多孔膜层。利用SEM观察膜层表面形貌,XRD测定膜层成分。通过对人骨髓间质干细胞(hMSCs)在多孔膜层表面粘附、增殖和分化能力的检测,评价纳米多孔结构对骨髓间质干细胞粘附、增殖和分化的影响。结果表明,阳极氧化可以在钛表面制备出互相贯穿的三维纳米多孔网络膜层。膜层由钛酸钠构成。与纯钛表面相比,三维纳米多孔钛表面具有更优异的生物相容性,能够明显促进hMSCs的粘附、增殖和分化。
Anodizing is used to build three-dimensional nanoporous film on the surface of pure titanium. The surface morphology of the film was observed by SEM and the film composition was determined by XRD. The adhesion, proliferation and differentiation of human bone marrow mesenchymal stem cells (hMSCs) on the surface of porous membrane were examined to evaluate the effect of porous structure on the adhesion, proliferation and differentiation of mesenchymal stem cells. The results show that the anodization can be prepared on the surface of titanium interpenetrating three-dimensional nano-porous network layer. The film consists of sodium titanate. Compared with pure titanium surface, three-dimensional nano-porous titanium surface has more excellent biocompatibility, can significantly promote hMSCs adhesion, proliferation and differentiation.