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给大鼠经口亚慢性染毒亚砷酸钠后,砷主要分布于肝细胞浆,其次为微粒体、线粒体,溶酶体及细胞核;随染毒时间延长各亚细胞器砷含量升高,且在微粒体和线粒体中所占的比例逐渐增大。除核外,各亚细胞器中均有分子量45000和24000蛋白结合砷(HMWP-As和LMWP-As)及6000小分子量砷结合物(LM-As)。微粒体和线粒体中LM-As从无到有,其占各自亚细胞器砷含量的比例逐渐增大,较HMWP-As和LMWP-As的变化似乎更明显,提示LM-As的生成可能与砷对微粒体和线体牡的损伤有关。
After oral administration of sodium arsenite to rats subcutaneously, arsenic was mainly distributed in the liver cytoplasm, followed by microsomes, mitochondria, lysosomes and nuclei. As concentrations of arsenic increased in subcellular organelles The proportion of microsomes and mitochondria gradually increases. In addition to nuclear, each subcellular organelle has a molecular weight of 45000 and 24000 protein binding arsenic (HMWP-As and LMWP-As) and 6000 small molecular weight arsenic conjugate (LM-As). The proportion of LM-As in the microsomes and mitochondria from scratch was gradually increased, which was more obvious than that of HMWP-As and LMWP-As, suggesting that the formation of LM-As may be related to arsenic Microsomes are related to the damage of the line body.