论文部分内容阅读
α-葡萄糖苷酶抑制剂(AGIs)是一类以延缓肠道糖类吸收而达到治疗糖尿病的口服降糖药物。从海洋天然产物宝库中寻找新型α-葡萄糖苷酶抑制剂对发现高效低毒的治疗II型糖尿病(T2DM)药物具有重要意义。本文综述了45个海洋动物、植物以及微生物来源的天然α-葡萄糖苷酶抑制剂的结构、活性及其生物来源,还简要探讨了其构效关系,即酚羟基、卤素和不饱和双键、叁键的存在有助于增强化合物的α-葡萄糖苷酶抑制活性。
Alpha-glucosidase inhibitors (AGIs) are a class of oral antidiabetic drugs that delay the intestinal absorption of carbohydrates to treat diabetes. Looking for a novel α-glucosidase inhibitor from the marine natural product treasure house is of great importance for the discovery of high and low toxicity drugs for treating type 2 diabetes (T2DM). This review summarizes the structures, activities and biological origins of natural α-glucosidase inhibitors from 45 marine animals, plants and microorganisms. The structure-activity relationship of phenolic hydroxyl, halogen and unsaturated double bonds, The presence of the triple bond helps to enhance the alpha-glucosidase inhibitory activity of the compound.