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AIM:To study the correlation between pancreatic phaseCT enhancement,intratumor microvessel density (MVD) andpathologic grading of pancreatic carcinoma and to evaluatethe relationship between the degrees of CT enhancementand malignancy of pancreatic carcinoma.METHODS:Thirty four patients with pancreatic carcinomaunderwent CT scanning before resection.The enhancementdegrees and forms of tumor were observed in pancreaticphase.The operative sample was stained with HE and CD34marked by immunohistochemistry.MVD and histopathologicalgrades of pancreatic carcinoma were examined.CTenhancement of the tumor,IVIVD counting in hot spot areasof neoplastic parenchymal cells and pathological grades ofpancreatic carcinoma were comparatively analyzed.RESULTS:Highly differentiated pancreatic adenocarcinomawas identified in 16 patients,moderately-differentiatedtumor in 7 and poorly-differentiated in 11.Isodensity CTenhancement was demonstrated in 13 cases,slightly lowdensity enhancement in 9,slightly low density enhancementwith small cystic lesions in 9 and slightly low densityenhancement with large cystic lesions in 3.The counting ofMVD with CD34 marked by immunohistochemistry in hotspot areas of neoplastic parenchyma cells was small in 10cases,medium in 16 and large in 8.The pathological gradescorrelated well with CT enhancement of the tumor (r=0.7857,P<0.001) and with MVD counting of tumor (r=0.3613,P<0.05).The CT enhancement of tumor correlated withMVD(r=0.6768,P<0.001).CONCLUSION:There is an obvious and significant correlationbetween CT enhancement,pathological grades and MVDnumber in the hot spot areas of tumor.The extent of CTenhancement is inversely proportional to the malignantdegree of pancreatic carcinoma,and to the MVD number inthe hot spot areas of neoplastic parenchyma.The MVD inthe hot spot areas of neoplastic parenchyma cells can alsoreflect the prognosis of the patients,and is directlyproportional to the malignant degree of pancreaticcarcinoma.
AIM: To study the correlation between pancreatic phase CT enhancement, intratumor microvessel density (MVD) and evaluate the relationship between the degrees of CT enhancement and malignancy of pancreatic carcinoma. METHODS: Thirty four patients with pancreatic carcinoma underwent CT scanning before resection. The enhancement degrees and forms of tumor were observed in pancreatic phase. The operative sample was stained with HE and CD34 marked by immunohistochemistry. MV and histopathological grades of pancreatic carcinoma were examined. CT Enhancement of the tumor, IVIVD counting in hot spot areas of neoplastic parenchymal cells and pathological grades of pancreatic The patients were comparatively analyzed. RESULTS: Highly differentiated pancreatic adenocarcinoma was identified in 16 patients, moderately-differentiated tumor in 7 and poorly-differentiated in 11. Isodensity CTenhancement was demonstrated in 13 cases, slightly low density enhancement in 9, slightly low density enhancement with small cystic lesions in 9 and slightly low density enhances with large cystic lesions in 3. The counting of MVD with CD34 marked by immunohistochemistry in hotspot areas of neoplastic parenchyma cells was small in 10cases, medium in 16 and large in 8. The pathological grades correlated well with CT enhancement of the tumor (r = 0.7857, P <0.001) and with MVD counting of tumor (r = 0.3613, P < There is an obvious and significant correlation between CT enhancement, pathological grades and MVD number in the hot spot areas of the tumor. The extent of CTenhancement is inversely proportional to the malignant dedegree of pancreatic carcinoma, and to the MVD number inthe hot spot areas of neoplastic parenchyma. MVD inthe hot spot areas of neoplastic parenchyma cells can alsoreflect the prognosis of the patients, and is directlyproportional to the malignant degree of pancreaticcarcinoma.