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我们在家兔结扎冠状动脉后再恢复血液灌注的模型上,观察了山莨菪碱对再灌注心律失常和血流动力学的影响。36只家兔于再灌前1min分别iv生理盐水,山莨菪碱0.5,1.0或5.0mg/kg。结果发现:山莨菪碱表现出剂量依赖性地降低再灌注心律失常的发生率。在5.0mg/kg时,使再灌注心律失常的发生率从83%下降至12.5%(P<0.01),并能加速LVSP,左室±dp/dt_(mas)和LVEDP的恢复过程。表明山莨菪碱能预防再灌注心律失常和改善再灌注时的心功能。
We ligated the coronary artery in rabbits and then returned to the model of blood perfusion, observed anisodamine on reperfusion arrhythmia and hemodynamics. Thirty-six rabbits were given iv saline, anisodamine 0.5, 1.0 or 5.0 mg / kg respectively 1 min before reperfusion. The results showed that anisodamine showed a dose-dependent reduction in the incidence of reperfusion arrhythmias. At 5.0 mg / kg, the incidence of reperfusion arrhythmia decreased from 83% to 12.5% (P <0.01) and accelerated the recovery of LVSP, ± dp / dt mas and LVEDP. Show that anisodamine can prevent reperfusion arrhythmia and improve heart function during reperfusion.