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难以与受体结合,结果只有两点吻合,表现在药理作用上也弱(图3B)所以“三点结合方式的观点,使肾上腺素两种异构体药理活性的显著差异得到解释。又如同一化合物的几何异构体,各基团间的空间位置和距离各不相同,因此其中只有一个异构体的空间结构适应于某一受体,因而药理效应必然有差异。如反式已烯雌酚的效力较顺式异构体约强7—10倍,
Difficult to bind to the receptor, the result is only two points coincide, the performance of the pharmacological effects are weak (Figure 3B) Therefore, "three point of view of the combination of the adrenergic two isomers pharmacological significant differences were explained. The geometrical isomers of a compound have different space positions and distances among the groups, and therefore only one of the isomers has a spatial structure adapted to one of the receptors, so the pharmacological effects inevitably have differences, such as trans-hexene The potency of the testosterone is about 7-10 times stronger than that of the cis-isomer,