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目的与方法：用气相色谱－质谱法测定血芬太尼浓度研究非紫绀先心病小儿心内直视手术中大剂量芬太尼麻醉的药代动力学。结果：芬太尼的药代动力学符合开放性三室模型，其药代动力学参数ｔ１／２π、ｔ１／２α、ｔ１／２β分别为２．８ｍｉｎ、２５．２ｍｉｎ和２３２．２ｍｉｎ；Ｖｄ和Ｃｌ分别为４．８９Ｌ／ｋｇ和５６５．６ｍｌ·ｋｇ－１·ｍｉｎ－１。结论：本麻醉方法其血浆芬太尼浓度不能有效地抑制机体的应激反应，必须辅助小剂量吸入麻醉药。在体外循环结束后应适当补充芬太尼，方可有效地提高血浆芬太尼的治疗浓度，抑制有害的应激反应，维持血流动力学的稳定。
PURPOSE AND METHODS: Determination of fentanyl concentration by gas chromatography-mass spectrometry The pharmacokinetics of high-dose fentanyl anesthesia in open-heart surgery in children with non-cyanotic congenital heart disease. Results: The pharmacokinetics of fentanyl was in accordance with the open three-compartment model with pharmacokinetic parameters t1 / 2π, t1 / 2α and t1 / 2β of 2.8 min, 25.2 min and 232.2 min, respectively. Vd and Cl Respectively 4.89L / kg and 565.6ml · kg-1 · min-1. Conclusion: The anesthetic method of plasma concentration of fentanyl can not effectively inhibit the body’s stress response, must assist small doses of inhaled anesthetics. Fentanyl should be properly added after cardiopulmonary bypass, which can effectively increase the therapeutic concentration of fentanyl in plasma, inhibit the harmful stress reaction and maintain the hemodynamic stability.