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患者女,37岁,因甲状腺机能亢进症,于2001年7月9日开始口服甲巯咪唑片(他巴唑)10mg,tid治疗。患者治疗前血常规正常。服药1个月后,出现白细胞、粒细胞急进性下降。最低白细胞降至0.9×10~9·L~(-1),中性粒细胞降至0.35。考虑为甲巯咪唑所致的急性粒细胞缺乏症。停用甲巯咪唑,给予非格司亭(津恤力)150μg,im,qd;瑞白100μg,im,qd;小聚胺(升白安)40mg,po,tid 螺旋藻(施普瑞)3片,po,tid;小牛胸腺肽片60mg,po,tid;维生素B_4 10mg,po,tid;鲨肝醇片50mg,po,tid等药促进白细胞再生及对症治疗。治疗10天后,患者白细胞及中性粒细胞恢复至正常。
Female, 37 years old, due to hyperthyroidism, on July 9, 2001 oral methimazole tablets (methimazole) 10mg, tid treatment. Patients before treatment of blood normal. After taking medicine for 1 month, white blood cells appeared and the rate of granulocyte decreased sharply. The lowest leukocyte dropped to 0.9 × 10 ~ 9 · L ~ (-1) and neutrophil decreased to 0.35. Consider methimazole-induced acute agranulocytosis. Dexamethasone (dexamethasone) 150μg, im, qd; Swiss white 100μg, im, qd; small polyamine 40mg, po, tid spirulina 3 tablets, po, tid; calf thymus tablets 60mg, po, tid; vitamin B_4 10mg, po, tid; batyl alcohol tablet 50mg, po, tid and other drugs to promote leukocyte regeneration and symptomatic treatment. After 10 days of treatment, the patient’s white blood cells and neutrophils returned to normal.