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目的:探讨急性时相蛋白在化疗患者真菌感染中的临床意义。方法:采用速率散射比浊法对化疗患者真菌感染诊治过程中C-反应蛋白、血清淀粉样蛋白A、α1-酸性糖蛋白、铜蓝蛋白进行检测。结果:化疗患者4种急性时相蛋白浓度显著高于正常对照(P<0.01);真菌感染后,4种急性时相蛋白明显升高,其升幅高于病毒感染组(血清淀粉样蛋白A除外)而低于细菌感染组(P<0.01),治疗有效者第3天已有下降,7天明显下降(P<0.01),至21天恢复至化疗未感染组水平(P>0.05),死亡组仍维持高水平;与白细胞计数比较,急性时相蛋白对真菌感染的监测更为灵敏。结论:监测急性时相蛋白对化疗患者真菌感染的诊断、疗效和预后评估有较大价值。
Objective: To investigate the clinical significance of acute phase protein in patients with fungal infection of chemotherapy. Methods: The rates of C-reactive protein, serum amyloid A, α1-acidic glycoprotein and ceruloplasmin in the diagnosis and treatment of patients with fungal infection were detected by rate nephelometry. Results: The concentrations of four acute phase proteins in patients with chemotherapy were significantly higher than those in the normal controls (P <0.01). After the fungal infection, the protein levels of the four acute phases were significantly higher than those in the virus-infected groups (except serum amyloid A (P <0.01). The effective rate of treatment was decreased on the 3rd day and decreased significantly on the 7th day (P <0.01), and returned to the level of the uninfected group after 21 days (P> 0.05) The group remained high; acute phase proteins were more sensitive to fungal infections than leukocyte counts. Conclusion: It is of great value to monitor the acute phase protein in the diagnosis, curative effect and prognosis evaluation of patients with fungal infection.