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目的了解长春市体检者的血清尿酸水平及其相关危险因素,以便有针对性的进行有效干预,降低本地区的高尿酸血症及其相关疾病的患病率。方法选取2013年1月至9月在一汽总医院体检中心进行健康体检者16 807例(来自不同职业),均符合研究要求且资料完整。其中男性9 736例,女性7 071例,平均年龄(37.46±10.43)岁。结果高尿酸血症的患病率为20.20%(3 395/16 807),高尿酸血症患者男性2 930例(30.09%),女性465例(6.58%)。不同年龄段男性高尿酸血症发病率均显著高于女性(P均<0.01);不同性别、年龄职工的尿酸水平随年龄增长呈“V”形曲线变化,不同年龄职工尿酸水平比较有统计学差异(P<0.05);高尿酸血症多因素logistic回归分析结果显示性别、高密度脂蛋白是高尿酸血症的保护因素;舒张压升高、超重、总胆固醇、甘油三酯是高尿酸血症的危险因素。结论长春市体检人群高尿酸血症的患病率较高,应引起医务人员高度重视,注重健康宣教,有针对性的进行健康干预,对预防本病及其相关疾病有重要意义。
Objective To understand the serum uric acid level and its related risk factors in Changchun City, so that effective intervention can be targeted and the prevalence of hyperuricemia and its related diseases can be reduced in this area. Methods From January 2013 to September 2013, 16 807 cases (from different professions) who carried out physical examinations in the examination center of FAW General Hospital were all eligible for the study and the data were complete. There were 9,736 males and 7071 females, with an average age of 37.46 ± 10.43 years. Results The prevalence of hyperuricemia was 20.20% (3 395/16 807). Among hyperuricemia patients, 2 930 (30.09%) were male and 465 (6.58%) were female. The prevalence of hyperuricemia in men of all ages were significantly higher than that in women (all P <0.01). The uric acid levels of workers of different sexes and ages changed with the curve of “V” in age. The uric acid levels of workers of different ages (P <0.05). The multivariate logistic regression analysis of hyperuricemia showed that sex and high density lipoprotein were the protective factors of hyperuricemia. The diastolic blood pressure, overweight, total cholesterol and triglyceride were high Risk factors for uric acid. Conclusions The prevalence of hyperuricemia in Changchun physical examination population is high, which should be paid great attention to by medical personnel. Paying attention to health education and targeted health intervention is of great significance in the prevention of this disease and its related diseases.