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目的本研究通过免疫组化方法检测初诊弥漫大B细胞淋巴瘤(DLBCL)患者淋巴组织GST-π、Topo-Ⅱ的表达,探讨初诊DLBCL患者上述指标表达的临床意义以及与IPI积分的相关性。方法收集福建省立医院病理科存档的2006年10月1日至2010年10月1日期间,首次确诊DL-BCL且接受化疗(CHOP或R-CHOP方案)≥2疗程患者标本34例(其中27例完成6个疗程化疗),检测GST-π、Topo-Ⅱ的表达。入选病例根据国际预后指数(IPI)进行评分,将评分结果分别与所检测指标的表达结果进行相关分析;将患者2、6个疗程化疗后疗效分别与IPI积分、上述两项结果进行相关分析。结果 GST-π、Topo-Ⅱ高表达与IPI评分密切相关,其阳性表达与IPI评分呈正相关。2个疗程化疗疗效及6个疗程化疗疗效都与两项指标呈正相关。结论在初治DLBCL患者中,GST-π、To-po-Ⅱ高表达与不良预后相关。
ObjectiveTo study the expression of GST-π and Topo-Ⅱ in lymphoid tissues of newly diagnosed diffuse large B cell lymphoma (DLBCL) by immunohistochemistry, and to explore the clinical significance of the expression of these indexes and the correlation with IPI score in newly diagnosed DLBCL patients. Methods Thirty-four patients with DL-BCL who were initially diagnosed with DL-BCL and were treated with chemotherapy (CHOP or R-CHOP regimen) ≥2 courses were collected from October 1, 2006 to October 1, 2010 in Department of Pathology, Fujian Provincial Hospital 27 cases completed 6 courses of chemotherapy), detected GST-π, Topo-Ⅱ expression. The selected cases were scored according to the International Prognostic Index (IPI), and the scores were correlated with the expression of the detected indexes respectively. The patients were treated with 2 and 6 courses of chemotherapy after treatment with IPI score and the above two results were analyzed. Results The high expression of GST-π and Topo-Ⅱ was closely related to the IPI score. The positive expression of GST-π and Topo-Ⅱ was positively correlated with the IPI score. Two courses of chemotherapy and six courses of chemotherapy efficacy are positively correlated with the two indicators. Conclusions In newly diagnosed DLBCL patients, the high expression of GST-π and To-po-Ⅱ is associated with poor prognosis.