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鉴于动物肾病综合征和慢性肾衰模型中口服血管转化酶(ACE)抑制剂(巯甲丙脯酸)可显著地降低蛋白尿,作者用ACE抑制剂对8名难治性持续蛋白尿儿童进行治疗。这8例病人均有持续的蛋白尿,曾用正规皮质醇或细胞毒药物治疗无效。肾病性蛋白尿的定义为晨尿尿蛋白/肌酐或定时尿蛋白排出率分别大于1.8(mg/mg)或40mg/m~2/hr,硫甲丙脯酸开始用12.5～25mg(0.33～1.0mg/kg/dose),每日3次,按血压和蛋白尿的改变,增至最大剂量50mg(1～2 mg/kg/dose),每日3次。用此药时服用的其它药物不变。结果 8名患者(女5例)平均年龄14.9(5～22)岁。狼疮性肾病4例,局灶节段性肾小
Given that oral administration of angiotensin converting enzyme (ACE) inhibitor (Captopril) can significantly reduce proteinuria in animal nephrotic syndrome and chronic renal failure models, the authors used ACE inhibitors to treat eight refractory persistent proteinuria children treatment. All 8 patients had persistent proteinuria and had been ineffective with normal cortisol or cytotoxic drugs. Nephrotic proteinuria was defined as morning urine peptic proteinuria / creatinine or urinary protein excretion rate were greater than 1.8 (mg / mg) or 40mg / m ~ 2 / hr, thalidomide began with 12.5 ~ 25mg (0.33 ~ 1.0 mg / kg / dose) three times a day, according to changes in blood pressure and proteinuria, to a maximum dose of 50mg (1 ~ 2 mg / kg / dose) three times a day. Other drugs taken with this medicine remain unchanged. Results The average age of 8 patients (5 female) was 14.9 (5-22) years old. 4 cases of lupus nephropathy, focal segmental renal small