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目的:探讨连续性肾脏替代治疗对慢性重度心力衰竭患者的临床价值。方法:选择慢性重度心力衰竭患者,测定血清C反应蛋白和N端利钠肽前体水平,比较其在常规治疗和连续性肾脏替代治疗前后的变化。结果:慢性重度心力衰竭患者血清C反应蛋白、血清N端利钠肽水平高于正常对照组(P<0.01);治疗后,连续性肾脏替代治疗组C反应蛋白、N端利钠肽前体较常规治疗组明显降低(P<0.01)。结论:连续性肾脏替代治疗可降低慢性重度心力衰竭患者血清C反应蛋白和N端利钠肽前体的水平,可在一定程度上干预慢性重度心力衰竭的发展及其预后。
Objective: To investigate the clinical value of continuous renal replacement therapy in patients with chronic severe heart failure. Methods: Patients with chronic severe heart failure were selected for determination of serum C-reactive protein and N-terminal pro-brain natriuretic peptide levels before and after routine treatment and continuous renal replacement therapy. Results: Serum C-reactive protein and serum N-terminal natriuretic peptide were significantly higher in patients with chronic severe heart failure than those in the normal control group (P <0.01). After treatment, C-reactive protein, N-terminal pro- Compared with the conventional treatment group was significantly lower (P <0.01). CONCLUSIONS: Continuous renal replacement therapy can reduce serum C-reactive protein and N-terminal pro-brain natriuretic peptide levels in patients with chronic severe heart failure and may interfere with the progression and prognosis of chronic severe heart failure to a certain extent.