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目的 :探讨大肠癌CD4 4 V6,E cadherin的表达对大肠癌的进展和转移的意义。方法 :应用SP免疫组化技术检测 56例大肠癌标本的CD4 4 V6,E cadherin的表达。结果 :CD4 4 V6表达有转移者 84 9%( 2 8/ 33) ,无转移者 39 1% ( 9/ 2 3)。E cadherin表达有转移者 2 4 2 % ( 8/ 2 3) ,无转移者 52 2 % ( 12 / 2 3) ,两者与肿瘤转移明显相关 (P <0 0 5)。结论 :对大肠癌组织进行CD4 4 V6,E cadherin的表达检测 ,有助于预测大肠癌的进展程度和转移的判断 ,以及评估预后
Objective : To investigate the significance of the expression of CD4 4 V6 and E cadherin in colorectal cancer on the progression and metastasis of colorectal cancer. Methods : The expression of CD4 4 V6 and E cadherin in 56 specimens of colorectal cancer was detected by SP immunohistochemical technique. Results: There were 84 9% (28/33) of CD4 4 V6 metastasis and 39 1% (9/23) of non-metastasis. E cadherin expression was found in 442 (8/23) patients with metastases and 52 (2/23) patients without metastases. Both were significantly associated with tumor metastasis (P < 0.05). Conclusion : The detection of CD4 4 V6 and E cadherin expression in colorectal cancer tissue can help predict the degree of progression and metastasis of colorectal cancer, and evaluate the prognosis.