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目的:观察重组葡激酶(r-SaK)对中国实验小型猪冠状动脉血栓、心肌缺血、心肌梗塞的影响.方法:直接电刺激中国实验小型猪冠状动脉造成动脉内膜损伤,逐渐形成冠脉内血栓.运用冠状动脉病理切片、显微成像、多媒体图象分析、心外膜电图、心肌组织化学染色、血清生化酶学检查、血液流变学等多种试验手段,研究了r-SaK静脉给药对冠脉血栓的溶栓作用.结果:r-SaK对冠脉血栓有显著的溶栓作用,与对照组比较,r-SaK两个剂量组均能明 显缩小冠脉血栓横切面积(P<0.01),减轻心肌缺血程度和范围(P<0.01),缩小梗塞区(P<0.01),降低CPK活性和血液粘度(P<0.05),抑制血小板粘附、血小板聚集及纤维蛋白原的形成(P<0.05).结论:r-SaK对冠状动脉血栓具有明显的溶栓作用,并可对抗心肌缺血、心肌梗塞等病理反应.
Objective: To observe the effects of recombinant staphylokinase (r-SaK) on coronary artery thrombosis, myocardial ischemia and myocardial infarction in experimental mini-pigs.Methods: Direct electrical stimulation of coronary artery of Chinese mini-pig caused arterial intimal injury and gradually formed coronary artery Thrombosis.Using a variety of experimental methods such as coronary artery pathological section, microscopic imaging, multimedia image analysis, epicardiogram, myocardial histochemical staining, serum biochemical enzymatic examination, hemorheology and so on, the effects of r-SaK Intravenous administration of thrombolytic effect of coronary thrombosis.Results: r-SaK on coronary thrombosis significant thrombolysis, compared with the control group, r-SaK two doses can significantly reduce the cross-sectional area of coronary thrombosis (P <0.01), alleviate the extent and range of myocardial ischemia (P <0.01), reduce infarct size (P <0.01), decrease CPK activity and blood viscosity (P <0.05), inhibit platelet adhesion, platelet aggregation and fibrin (P <0.05) .Conclusion: r-SaK has obvious thrombolytic effect on coronary thrombosis and can resist pathological changes such as myocardial ischemia and myocardial infarction.