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急性疼痛发作是镰状细胞性疾病的主要症状之一,本文总结、分析其发生率和影响因素等流行病学资料。3578例镰状细胞性疾病患者为1979年至1988年美国23个临床中心随访的可供分析的病例,年龄范围从初生至66岁,病种包括镰状细胞贫血(SS)、镰状β°-地中海贫血(Sβ°)、镰状B(?)-地中海贫血(Sβ(?))和血红蛋白SC 病(SC)。在18356名患病年的观察中,共有12290次疼痛发作。各疾病疼痛发生率差异较大;SS 患者为(次/患病年)0.8、Sβ°为1.0、SC 和Sβ(?)均为0.4。同一疾
Acute pain episodes are one of the main symptoms of sickle cell disease. This article summarizes and analyzes epidemiological data such as its incidence and influencing factors. The 3578 patients with sickle cell disease were eligible for follow-up in 23 clinical centers in the United States from 1979 to 1988, ranging in age from primary to 66 years old. The disease types included sickle cell anemia (SS), sickle β ° - thalassemia (Sβ °), sickle B (?) - thalassemia (Sβ (?)) And hemoglobin SC disease (SC). In the 18,356 years of observation, there were 12290 episodes of pain. The prevalence of pain varied significantly among the various diseases; SS was 0.8 (subscales / years of illness), 1.0 for Sβ °, and 0.4 for SC and Sβ (?). The same illness