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目的 探讨TTV病毒在不明原因肝炎中的意义及其所致肝损害的临床特征。方法 套式聚合酶链反应检测血清TTV病毒DNA并对TTV病毒阳性病例进行临床分析。结果 病原不明肝炎中TTV 病毒感染率为38-6 % ;均为散发病例,多见于青壮年,男女无差别;症状明显,黄疸常见,血清转氨酶中度升高;肝组织呈汇管区炎症;一般病例预后良好,但合并症易加重病情。结论 TTV病毒可以解释病原不明肝炎中的部分病因
Objective To investigate the significance of TTV virus in hepatitis with unexplained hepatitis and its clinical characteristics of liver damage. Methods The serum TTV DNA was detected by nested polymerase chain reaction (PCR) and the clinical data of TTV virus positive cases were analyzed. Results The prevalence of TTV in unidentified hepatitis was 38-6%. All of them were sporadic cases, more common in young adults. There was no difference between men and women. The symptoms were obvious, the jaundice was common, and the level of serum aminotransferase was moderately increased. The liver tissue showed inflammation in portal area. The prognosis is good, but the complication tends to aggravate the condition. Conclusion TTV virus can explain part of the etiology of hepatitis with unknown pathogen