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目的探讨N末端B型利钠肽前体(NT-pro BNP)与超敏C反应蛋白(hs-CRP)对急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)患者预后的预测价值。方法 100例行PCI手术治疗的AMI患者,根据术后转归情况分为恶化组(26例)与良好组(74例),两组患者均于术前、术后第1天、术后第3天采用免疫比浊法检测NT-pro BNP与hs-CRP水平,并进行比较。结果术前两组患者NT-pro BNP、hs-CRP水平比较差异无统计学意义(P>0.05)。恶化组术后第1、3天NT-pro BNP、hs-CRP水平均术前依次升高,良好组术后第1、3天NT-pro BNP、hs-CRP水平较术前依次下降,差异均具有统计学意义(P<0.05);且恶化组术后第1、3天NT-pro BNP水平[(1105.76±282.35)、(1267.47±306.72)pg/ml]、hs-CRP水平[(71.03±12.37)、(82.75±13.09)mg/L]均高于良好组[(952.73±212.34)、(754.32±106.79)pg/ml,(46.35±7.89)、(38.15±7.01)mg/L],差异均具有统计学意义(P<0.05)。结论 AMI患者PCI术后NTpro BNP、hs-CRP水平增高,提示预后不良。
Objective To investigate the predictive value of N-terminal pro-BNP and hs-CRP in the prognosis of patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Methods One hundred patients with AMI who underwent PCI were divided into two groups according to the postoperative outcome: worsening group (n = 26) and good group (n = 74). The patients in both groups were preoperatively, on the first postoperative day, The levels of NT-pro BNP and hs-CRP were measured by immunoturbidimetry on day 3, and compared. Results There was no significant difference in the levels of NT-pro BNP and hs-CRP between the two groups before surgery (P> 0.05). The levels of NT-pro BNP and hs-CRP in malignant group increased preoperatively on the 1st and 3rd postoperative day, and the levels of NT-pro BNP and hs-CRP decreased on the 1st and 3rd postoperative day (P <0.05). The levels of NT-pro BNP [(1105.76 ± 282.35), (1267.47 ± 306.72) pg / ml] and hs-CRP ± 12.37 and 82.75 ± 13.09 mg / L, respectively] were higher than those in the control group [(952.73 ± 212.34), (754.32 ± 106.79) pg / ml, (46.35 ± 7.89) and (38.15 ± 7.01) mg / The differences were statistically significant (P <0.05). Conclusion The levels of NTpro BNP and hs-CRP in patients with AMI after PCI are higher than those in patients with AMI, suggesting a poor prognosis.