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目的观察水飞蓟宾胶囊对非酒精性脂肪性肝病(NAFLD)患者血清白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)的影响。方法58例NAFLD患者随机分为2组。治疗组29例,给予水飞蓟宾胶囊70mg,每日3次。对照组29例给予葡醛内酯片100mg,每日3次。两组同时给予控制饮食和适当锻炼,疗程30d。检测治疗前后患者血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、IL-8、TNF-α水平。结果治疗后两组患者血清ALT、AST、IL-8、TNF-α水平均有改善(P<0.01),但治疗组明显优于对照组(P<0.01)。结论水飞蓟宾胶囊可降低NAFLD患者血清IL-8、TNF-α从而改善肝功能。
Objective To observe the effects of silybin on serum levels of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in patients with nonalcoholic fatty liver disease (NAFLD). Methods 58 patients with NAFLD were randomly divided into two groups. Treatment group, 29 cases, given silybin capsule 70mg, 3 times a day. Control group, 29 cases were given glucurolaide tablets 100mg, 3 times a day. Both groups were given control diet and appropriate exercise, treatment 30d. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), interleukin-8 and tumor necrosis factor-α levels were measured before and after treatment. Results The levels of serum ALT, AST, IL-8 and TNF-α in both groups were improved after treatment (P <0.01), but the treatment group was significantly better than the control group (P <0.01). Conclusion Silybin capsules can reduce serum levels of IL-8 and TNF-α in NAFLD patients and improve liver function.