丙肝与乙肝病毒感染在原发性肝癌病因学上的相互关系研究

• 作 者: 张振权 黄天壬 何振芳 余家华 徐庆芬 黄昭东
• 机 构: 广西区肿瘤研究所,广西区肿瘤研究所,广西区肿瘤研究所,广西区肿瘤研究所,广西区肿瘤研究所,广西区肿瘤研究所,
• 出 处: 广西医学
• 发表日期: 1993年03期
• 关键词: 乙肝病毒感染 原发性肝癌 乙型肝炎病毒 丙型肝炎病毒 丙肝病毒 研究人群 病因学 肝癌高发区 上海实业科华 非结构区抗原

对78名原发性肝癌(PLC)死者及其匹配对照(262名)的贮存血清进行的研究表明,丙肝病毒(HCV)感染者死于PLC的危险性为非HCV感染者的3倍左右,研究人群中约有四分之一的PLC死亡可归因于与HCV感染有关。作为PLC危险因素,HCV感染与乙肝病毒(HBV)感染互不产生明显的混淆作用。这两种感染在人群中的分布互不受对方的影响。这些结果说明,对于PLC的预防,固然要重视防治HBV感染,也不宜忽略防治HCV感染。

A study of stock sera from 78 deceased patients with PLC and their matched controls (262) showed that the risk of dying from PLC in HCV-infected patients was about 3 times higher than that in non-HCV-infected patients, Approximately one-quarter of PLC deaths in the study population are attributable to HCV infection. As a PLC risk factor, HCV infection and hepatitis B virus (HBV) infection do not produce any significant confusion. The distribution of these two infections in the population is independent of each other. These results show that, for the prevention of PLC, although attention should be paid to prevention and treatment of HBV infection, it should not ignore the prevention and treatment of HCV infection.